tag:blogger.com,1999:blog-31395585062190784702024-02-19T23:30:44.709-08:00NeurofibromatosisVictoria G.http://www.blogger.com/profile/08631638409492517458noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-3139558506219078470.post-90149552356978311302012-11-28T13:43:00.004-08:002012-11-28T13:43:40.936-08:00Affect on Daily Life<br />
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<span style="font-family: Times, Times New Roman, serif;">NF1- mild, and individuals
live normal and productive lives. </span></div>
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<span style="font-family: Times, Times New Roman, serif;">NF2 varies greatly among
individuals. In some cases of NF2, the damage to nearby vital </span></div>
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<span style="font-family: Times, Times New Roman, serif;">structures,
such as other cranial nerves and the brain stem, can be life-threatening. </span></div>
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<span style="font-family: Times, Times New Roman, serif;">Most individuals with schwannomatosis have significant pain.
In some extreme cases the pain will </span></div>
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<span style="font-family: Times, 'Times New Roman', serif; text-indent: -0.38in;">be severe and disabling. </span></div>
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<span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><span style="background-color: white; line-height: 21px; text-indent: 0px;">Evans DG, Huson SM, Donnai D, Neary W, Blair V, et al. (1992) </span><span class="ref-title" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">A clinical study of type 2 neurofibromatosis</span><span style="background-color: white; line-height: 21px; text-indent: 0px;">. </span><span class="ref-journal" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">Q J Med</span><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="ref-vol" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">84</span><span style="background-color: white; line-height: 21px; text-indent: 0px;">: 603–618. </span><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">[<a href="http://www.ncbi.nlm.nih.gov/pubmed/1484939" ref="reftype=pubmed&article-id=3422319&issue-id=211079&journal-id=440&FROM=Article%7CCitationRef&TO=Entrez%7CPubMed%7CRecord&rendering-type=normal" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="pmc_ext">PubMed</a>]</span></span></div>
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<span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">National Institutes of Health </span></span></div>
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<a href="http://www.nih.gov/" style="font-family: Times, 'Times New Roman', serif; font-size: small; line-height: 21px; text-indent: 0px; white-space: nowrap;">www.nih.gov</a></div>
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Victoria G.http://www.blogger.com/profile/08631638409492517458noreply@blogger.com1tag:blogger.com,1999:blog-3139558506219078470.post-81106720186764849412012-11-28T13:33:00.004-08:002012-11-28T13:33:56.914-08:00New Research <br />
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<span style="font-family: Times, Times New Roman, serif;">Several years ago, research teams located the exact position of
the NF1 gene on chromosome 17. </span></div>
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<span style="font-family: Times, Times New Roman, serif;">The product of the NF1 gene is a large and
complex protein called neurofibromin, which is </span></div>
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<span style="font-family: Times, Times New Roman, serif;">primarily active
in nervous cells as a regulator of cell division. Intensive efforts have
led to the </span></div>
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<span style="font-family: Times, Times New Roman, serif;">identification of the NF2 gene on chromosome 22. </span></div>
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<span style="font-family: Times, Times New Roman, serif;"><br /></span></div>
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</div>
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<span style="font-family: Times, Times New Roman, serif;">The NF2 gene product is a tumor-suppressor protein called merlin. Ongoing research
continues to </span></div>
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<span style="font-family: Times, Times New Roman, serif;">discover additional genes that appear to play a role in NF-related
tumor suppression or growth. </span></div>
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<span style="font-family: Times, Times New Roman, serif;">Other research is aimed at understanding how
the genetic mutations that cause the benign tumors of </span></div>
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<span style="font-family: Times, Times New Roman, serif;">NF1 also cause nerve
cells and nerve networks to form abnormally during fetal development, which </span></div>
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<span style="font-family: Times, Times New Roman, serif;">later result in the learning disabilities and cognitive deficits of children
with the disorder. </span></div>
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<span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;"><br /></span></div>
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<span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;">Additional research is aimed at understanding the natural
history of tumors in NF2 and </span></div>
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<span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;">determining possible factors that may regular
their growth patterns. The </span><span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;">Interinstitute</span><span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;"> Medical </span></div>
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<span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;">Genetics Research Program at the NIH Clinical Center conducts NF2 family
history research. </span></div>
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<span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;">Using specimens from some of the families, scientists have
isolated and sequenced the NF2 </span></div>
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<span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;">gene and have described two different patterns
of clinical features in NF2 patients. </span></div>
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<span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;">Investigators are continuing to study
these patterns to see if they correspond to specific types </span></div>
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<span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;">of gene mutations. </span></div>
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<span style="font-family: Times, 'Times New Roman', serif; line-height: 80%; text-indent: -0.38in;"><br /></span></div>
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<span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><span style="background-color: white; line-height: 21px; text-indent: 0px;">McClatchey AI (2007) </span><span class="ref-title" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">Neurofibromatosis</span><span style="background-color: white; line-height: 21px; text-indent: 0px;">. </span><span class="ref-journal" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">Annu Rev Pathol</span><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="ref-vol" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">2</span><span style="background-color: white; line-height: 21px; text-indent: 0px;">: 191–216. </span><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">[<a href="http://www.ncbi.nlm.nih.gov/pubmed/18039098" ref="reftype=pubmed&article-id=3492274&issue-id=215208&journal-id=440&FROM=Article%7CCitationRef&TO=Entrez%7CPubMed%7CRecord&rendering-type=normal" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="pmc_ext">PubMed</a>]</span></span></div>
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<span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><span style="background-color: white; line-height: 21px; text-indent: 0px;">Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, et al. (2006) </span><span class="ref-title" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">A negative feedback signaling network underlies oncogene-induced senescence</span><span style="background-color: white; line-height: 21px; text-indent: 0px;">. </span><span class="ref-journal" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">Cancer Cell</span><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="ref-vol" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">10</span><span style="background-color: white; line-height: 21px; text-indent: 0px;">: 459–472.</span><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">[<a class="int-reflink" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692661/" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">PMC free article</a>]</span><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">[<a href="http://www.ncbi.nlm.nih.gov/pubmed/17157787" ref="reftype=pubmed&article-id=3492274&issue-id=215208&journal-id=440&FROM=Article%7CCitationRef&TO=Entrez%7CPubMed%7CRecord&rendering-type=normal" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="pmc_ext">PubMed</a>]</span></span></div>
Victoria G.http://www.blogger.com/profile/08631638409492517458noreply@blogger.com0tag:blogger.com,1999:blog-3139558506219078470.post-8943523368172526012012-10-23T21:59:00.000-07:002012-11-28T13:48:19.913-08:00Treatment<br />
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</div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 200%; mso-bidi-font-weight: bold;">Surgery is often recommended to remove the tumors.
Some NF1 tumors may become cancerous, and treatment may include surgery,
radiation, or chemotherapy. Surgery, radiation, and chemotherapy also may be
used to control or reduce the size of optic nerve tumors when vision is
threatened. Some bone malformations can be corrected surgically.</span><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 200%;"><o:p></o:p></span></div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 200%; mso-bidi-font-weight: bold;">For NF2, improved diagnostic technologies, such as
MRI, can reveal tumors as small as a few millimeters in diameter, thus allowing
early treatment. Surgery to remove tumors completely is one option but may
result in hearing loss. Surgery also can correct cataracts and retinal
abnormalities.</span></div>
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</div>
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<span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 200%; mso-bidi-font-weight: bold;">There is no currently accepted medical treatment or
drug for schwanomatosis, but surgical management is often effective. Pain
usually subsides when tumors are removed completely. Genetic testing is
available for families with documented cases of NF1 and NF2 but such testing
for schwannomatosis currently does not exist. </span></div>
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<br /></div>
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<span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="ref-cit" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;"><span class="mixed-citation" id="__mixed-citationid1705541" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Kourea HP, Orlow I, Scheithauer BW, Cordon-Cardo C, Woodruff JM (1999) <span class="ref-title" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas</span>. <span class="ref-journal" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Am J Pathol</span> <span class="ref-vol" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">155</span>: 1855–1860. <span class="nowrap" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline; white-space: nowrap;">[<a class="int-reflink" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866948/" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">PMC free article</a>]</span> <span class="nowrap" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline; white-space: nowrap;">[<a href="http://www.ncbi.nlm.nih.gov/pubmed/10595915" ref="reftype=pubmed&article-id=3490977&issue-id=215208&journal-id=440&FROM=Article%7CCitationRef&TO=Entrez%7CPubMed%7CRecord&rendering-type=normal" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="pmc_ext">PubMed</a>]</span></span></span></span><br />
<span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><span style="background-color: white; line-height: 21px; text-indent: 0px;">Holtkamp N, Malzer E, Zietsch J, Okuducu AF, Mucha J, et al. (2008) </span><span class="ref-title" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy</span><span style="background-color: white; line-height: 21px; text-indent: 0px;">. </span><span class="ref-journal" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">Neuro Oncol</span><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="ref-vol" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;">10</span><span style="background-color: white; line-height: 21px; text-indent: 0px;">: 946–957.</span><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">[<a class="int-reflink" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719009/" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">PMC free article</a>]</span><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">[<a href="http://www.ncbi.nlm.nih.gov/pubmed/18650488" ref="reftype=pubmed&article-id=3490977&issue-id=215208&journal-id=440&FROM=Article%7CCitationRef&TO=Entrez%7CPubMed%7CRecord&rendering-type=normal" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="pmc_ext">PubMed</a>]</span></span></div>
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<br />Victoria G.http://www.blogger.com/profile/08631638409492517458noreply@blogger.com3tag:blogger.com,1999:blog-3139558506219078470.post-35570934110805964322012-10-07T22:15:00.002-07:002012-11-28T13:57:53.110-08:00TypesThere are 3 different types of Neurofibromatosis: Neurofibromatosis Type 1(NF1), Neurofibromatosis Type 2(NF2), and Schwannomatosis. In diagnosing NF1, a doctor looks for changes in skin appearanc, tumors, or bone abnormalites, and/or a parent, sibling or child with NF1. It affects about 1 in every 3,000 people, ranges from mild to severe, and can cause more symptoms in some people than others. Next is NF2, it's the less common form and may be evident to diagnose at birth and nearly always by the time the child is 10yrs old. It affects about 1 in every 25,000 people. Symptoms generally occur in the late teens and early 20's. However, some people experience symptoms in childhood and others not until age 40. Last is Schwanomatosis, which is once considered to be a variation of NF2. It grows on the peripheral nerves throughout the body, can cause severe, debilitating pain, and neurological dysfunction. Also, it's recognized most often in people over the age of 30.<span style="background-color: white; color: #4a4a4a; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 19px;"> </span><br />
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<span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><span style="background-color: white; color: #009933; line-height: 16.666667938232422px;">www.hopkinsmedicine.org › ... › </span><a href="https://www.google.com/url?url=http://www.hopkinsmedicine.org/neurology_neurosurgery/specialty_areas/neurofibromatosis/&rct=j&sa=X&ei=wFxyUOe7B8XS2gXrp4CIAg&ved=0CCsQ6QUoADAB&q=schwannomatosis&usg=AFQjCNGIdlMY67A4GotBoP38TD1No3Xw1w" style="background-color: white; color: #009933; cursor: pointer; line-height: 16.666667938232422px; text-decoration: initial;">Neurofibromatosis Center</a></span><br />
<span style="font-family: Times, Times New Roman, serif; font-size: x-small;">http://www.nfinc.org</span><br />
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<span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><span style="background-color: white; line-height: 21px; text-indent: 0px;">Halder G, Johnson RL. Hippo signaling: growth control and beyond. </span><span style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline;"><span class="ref-journal" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Development. </span>2011;<span class="ref-vol" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">138</span>:9–22. doi: 10.1242/dev.045500.</span><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">[<a class="int-reflink" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998162/" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">PMC free article</a>]</span><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21138973" ref="reftype=pubmed&article-id=3282898&issue-id=205761&journal-id=365&FROM=Article%7CCitationRef&TO=Entrez%7CPubMed%7CRecord&rendering-type=normal" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="pmc_ext">PubMed</a>]</span><span style="background-color: white; line-height: 21px; text-indent: 0px;"> </span><span class="nowrap" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; text-indent: 0px; vertical-align: baseline; white-space: nowrap;">[<a href="http://dx.crossref.org/10.1242%2Fdev.045500" ref="reftype=other&article-id=3282898&issue-id=205761&journal-id=365&FROM=Article%7CCitationRef&TO=Content%20Provider%7CCrosslink%7CDOI&rendering-type=normal" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="pmc_ext">Cross Ref</a>]</span></span></div>
<span style="font-family: Times, Times New Roman, serif; font-size: x-small;"><span style="background-color: white; line-height: 21px;"> </span><span class="ref-cit" style="background-color: white; border: 0px; font: inherit; line-height: 21px; margin: 0px; padding: 0px; vertical-align: baseline;"><span class="mixed-citation" id="__mixed-citationid1735317" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Lorenzo J, Barton B, Acosta MT, North KN. The mental motor and language development of toddlers with neurofibromatosis type 1. <span style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><span class="ref-journal" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">J Pediatr. </span>2011;<span class="ref-vol" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">158</span>:660–665. doi: 10.1016/j.jpeds.2010.10.001.</span> <span class="nowrap" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline; white-space: nowrap;">[<a href="http://www.ncbi.nlm.nih.gov/pubmed/21094952" ref="reftype=pubmed&article-id=3282898&issue-id=205761&journal-id=365&FROM=Article%7CCitationRef&TO=Entrez%7CPubMed%7CRecord&rendering-type=normal" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="pmc_ext">PubMed</a>]</span><span class="nowrap" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline; white-space: nowrap;">[<a href="http://dx.crossref.org/10.1016%2Fj.jpeds.2010.10.001" ref="reftype=other&article-id=3282898&issue-id=205761&journal-id=365&FROM=Article%7CCitationRef&TO=Content%20Provider%7CCrosslink%7CDOI&rendering-type=normal" style="border: 0px; color: #642a8f; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="pmc_ext">Cross Ref</a>]</span></span></span></span><br />
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Victoria G.http://www.blogger.com/profile/08631638409492517458noreply@blogger.com0tag:blogger.com,1999:blog-3139558506219078470.post-32364063117167551872012-10-07T21:27:00.000-07:002012-10-07T21:27:25.727-07:00What is this?Neurofibromatosis is a genetic neurological disorder that causes tumors or neurofibromas to grow in the nervous system. It can affect the brain, spinal cord, nerves, and skin. Neurofibromatosis can either be an inherited disorder or the product of a gene mutation. The majority of the affected people inherit the disorder. After the mutant gene causes the tumors to grow along the body, under the skin, it can be passed along to succeeding generations.<br />
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<span style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 11px; line-height: 16.633333206176758px;"> Neurofibromatosis. MedlinePlus. 2009 Available at: </span><a href="http://www.nlm.nih.gov/medlineplus/neurofibromatosis.html" style="background-color: white; color: #779068; font-family: Arial, Helvetica, sans-serif; font-size: 11px; line-height: 16.633333206176758px;" target="_blank">http:/<wbr></wbr>/<wbr></wbr>www.nlm.nih.gov/<wbr></wbr>medlineplus/<wbr></wbr>neurofibromatosis.html</a><span style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 11px; line-height: 16.633333206176758px;">. Accessed February 10, 2010.</span><br />
<span style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 11px; line-height: 16.633333206176758px;">Learning About Neurofibromatosis. National Human Genome Research Institute (NHGRI). 2009 Available at: </span><a href="http://www.genome.gov/14514225" style="background-color: white; color: #779068; font-family: Arial, Helvetica, sans-serif; font-size: 11px; line-height: 16.633333206176758px;" target="_blank">http:/<wbr></wbr>/<wbr></wbr>www.genome.gov/<wbr></wbr>14514225</a><span style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 11px; line-height: 16.633333206176758px;">. Accessed February 10, 2010.</span>Victoria G.http://www.blogger.com/profile/08631638409492517458noreply@blogger.com2